RAF Typhoon FGR4s have operated alongside France's air force in a combined operation against an subterranean weapons facility in Syrian territory used by the Islamic State group (IS), per a report from the British defence ministry.
The location, pinpointed through surveillance, was assessed as containing munitions and bombs, the release indicated, and was located in mountainous terrain just above the historic site of Palmyra in Syria's central region.
"Our aircraft employed precision-guided Paveway IV munitions to target a several approach shafts leading to the depot... preliminary assessments suggest the objective was successfully hit," the ministry announced.
There was no sign of any civilian casualties in the strike late on Saturday and every plane involved made a safe return, the defence officials confirmed.
The Typhoon fighters were supported by a Voyager refuelling tanker.
IS - alternatively referred to as Daesh - imposed militant control over significant areas in Iraq and Syria prior to its 2019 collapse.
"This strike shows British leadership, and commitment to work closely with our partners, to eliminate any revival of the terrorist group and their dangerous and violent ideologies in the region," Britain's Defence Chief the Defence Secretary said.
RAF aircraft have conducted overwatch operations over Syrian airspace to "prevent any efforts to regroup" of Islamic State subsequent to its routing at the battle of Baghuz in the year 2019, the ministry said.
"I must thank all the members of the UK armed forces participating in this mission for their skill and their courage," Healey said. "Including them were a great many UK service members on duty over Christmas and New Year. This action, to eliminate militants who endanger our way of life, highlights how UK forces are always on standby, continuously, protecting the UK at home and influential overseas."
In December, the US military carried out what it called a "massive strike" against Daesh sites in the country, following an assault resulted in the deaths of two American soldiers and a civilian linguist in Palmyra.
The U.N. says IS still has roughly 5-7 thousand fighters in both countries.